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Drug-related problems as a potential cause of hospitalizations
Očovská, Zuzana ; Vlček, Jiří (advisor) ; Trejtnar, František (referee) ; Urbánek, Karel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate PharmDr. Zuzana Očovská Supervisor prof. RNDr. Jiří Vlček, CSc. Title of Doctoral Thesis Drug-related problems as a potential cause of hospitalizations Introduction and objectives: A drug-related problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Manifested drug-related problems may contribute to hospital admissions of patients. Such hospital admissions, known as drug-related hospital admissions (DRA), represent a significant and potentially preventable burden on health systems. DRA often arise from the combination of multiple medications, making it important to pay increased attention to drug interactions, particularly in older patients who are taking a larger number of medications. DRA can result from inappropriate medication dosing or the selection of medications in the presence of chronic kidney disease. The main objectives of this thesis are: 1) to determine the prevalence and preventability of DRA and to identify medications and clinical manifestations associated with DRA in patients admitted to hospital via the department of emergency...
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Analysis of drug-drug interactions in patients admitted to hospital (II.)
Mašková, Daniela ; Vlček, Jiří (advisor) ; Malý, Josef (referee)
Candidate: Daniela Mašková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug-drug interactions in patients admitted to hospital (II.) 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Drug-drug interactions (DDIs) are part of drug-related problems. Drug-related problems can be either potential (possibly leading to real problems for the patient) or manifest (the problem already impacts the patient). This study aims to identify potential DDIs in the medication history of patients acutely admitted to University Hospital Hradec Králové via the department of emergency medicine. The objectives are to determine the prevalence of hospital admissions with at least one potential DDI in the medication history and characterize the identified potential DDIs with respect to their mechanism, severity rating, level of documentation, and potential consequences. Another objectives was to identify medication classes involved in potential DDI. The design of this study is an observational cross-sectional study. The data were obtained from the previous study examining the drug-relatedness of 1252 hospital admissions. For the purpose of my master's thesis, a sample of 378 hospital admissions was...
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Analysis of drug dosage adjustments in patients with chronic kidney disease
Procházková, Jana ; Vlček, Jiří (advisor) ; Doseděl, Martin (referee)
Candidate: Jana Procházková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug dosage adjustments in patients with chronic kidney disease 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Several medications excreted by the kidneys or associated with an increased risk for adverse drug events in patient with chronic kidney disease (CKD) require dosage adjustment, cautious use or avoidance. However, a number of studies show that appropriate dosage adjustment is not provided in many cases. Our objective was to analyze appropriateness of drug dosages and contraindicated medications in patients with CKD admitted to the hospital in Hradec Králové via the department of emergency medicine. This study is an observational cross-sectional study and represents a sub-study of the previous study that examined drug-relatedness of unplanned hospital admissions to University Hospital Hradec Králové in 2018. The data were obtained from electronic medical records. The appropriateness of drug use and drug dosages was analyzed in patients with an estimated glomerular filtration rate (eGFR) between 15 and 60 mL/min/1.73 m2 based on comparison with the Summary of Product Characteristics (SmPC). The...
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Analysis of drug-drug interactions in patients admitted to hospital (II.)
Mašková, Daniela ; Vlček, Jiří (advisor) ; Malý, Josef (referee)
Candidate: Daniela Mašková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug-drug interactions in patients admitted to hospital (II.) 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Drug-drug interactions (DDIs) are part of drug-related problems. Drug-related problems can be either potential (possibly leading to real problems for the patient) or manifest (the problem already impacts the patient). This study aims to identify potential DDIs in the medication history of patients acutely admitted to University Hospital Hradec Králové via the department of emergency medicine. The objectives are to determine the prevalence of hospital admissions with at least one potential DDI in the medication history and characterize the identified potential DDIs with respect to their mechanism, severity rating, level of documentation, and potential consequences. Another objectives was to identify medication classes involved in potential DDI. The design of this study is an observational cross-sectional study. The data were obtained from the previous study examining the drug-relatedness of 1252 hospital admissions. For the purpose of my master's thesis, a sample of 378 hospital admissions was...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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